What causes stem cells to age?

Question

Stem cells must endure a lot of stress and work, which in turn makes them age. So what are the factors that turn them old? First, where do they serve? Within an organ or a tissue? Which part? In the skin, they would serve multipotent stem cells residing in hair follicles, thus allowing for these cells to be damaged by environmental factors. The temperature also plays an important role, as temperature variations make stem cells hibernate, becoming inactive, then they return to use, by undergoing a highly programmed systemic response that triggers the amplification of strong inflammatory signals, which helps them stave off certain infections.

Answer 1

Stem cells undergo external and internal stress and start aging as a result. Even at the cellular and molecular levels, stem cells experience stress, particularly to some of their proteins, and remotely this factor becomes crucial in the aging process. There is a systemic failure that causes stem cells to cease functioning - specifically the mechanisms that protect stem cells from the accumulation of so-called protein ‘trash’ as the stem cells grow older. However, there is a response - stem cells trigger a protein termed heat shock factor one (HSF1), and this reduces protein trash and the regenerative potential is still there.